ARESTIN® is the first locally administered antibiotic (LAA) with Microspheres that has been proven to be more effective than scaling and root planing alone. Using ARESTIN® in combination with scaling and root planing significantly reduces pocket depths, kills the bacteria associated with periodontal disease, and decreases bleeding on probing. ARESTIN® kills the most common pathogens associated with periodontal disease. And, with its unique Microsphere technology, ARESTIN® maintains therapeutic drug concentrations for up to 21 days.